Interactions
Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy
Echinacea Interactions with Drugs Natural medicine practitioners sometimes caution that echinacea may lead to liver inflammation. There is not clear information from laboratory or human studies in this area. Nonetheless, caution should be used when combining echinacea by mouth with other medications that can harm the liver. Examples of such agents include anabolic steroids, amiodarone, methotrexate, acetaminophen (Tylenol®), and antifungal medications taken by mouth (such as ketoconazole). Echinacea may affect the way certain drugs are broken down by the liver.
In theory, echinacea's ability to stimulate the immune system may interfere with drugs that suppress the immune system (including azathioprine, cyclosporine, and steroids such as prednisone). Because clear human studies are lacking, people taking these drugs should consult a healthcare professional or pharmacist before using echinacea.
Based on one vague case report, taking echinacea along with amoxicillin may cause life-threatening reactions. However, the details of this case are not very clear.
Early information suggests that the use of echinacea with econazole nitrate cream (Spectazole®) on the skin may lower the frequency of vaginal yeast infections after treatment.
Many tinctures contain high levels of alcohol, and may cause nausea or vomiting when taken with metronidazole (Flagyl®) or disulfiram (Antabuse®).
Echinacea may also interact with anesthetics, antineoplastics, and caffeine. However, these potential interactions are not fully understood.